I think this is once again a personal preferance. I like my all my speakers set to large, as I find the dialogue for mens voices in movies a little too high and music sounds weak otherwise. I know the speakers don't reproduce clean sound this way and the speakers won't respond below their ratings very well if at all, but everything just sound fuller, richer to me. The bass in music is way better this way, fills the room more evenly. So I would suggest you try the settings one way then other for awhile and see which way you like it best.
BTW, my system is:
Denon1804
M22's Fronts
3QS8's for surrounds and rear
VP100 Center
Dbox David 250 sub


Jason
M80 v2
VP160 v3
QS8 v2
PB13 Ultra
Denon 3808
Samsung 85" Q70