Sounds like a GREAT setup that you've got there. Or will have. . .
I would have to agree with going with M60's over the 22's. I started with 22's and quite enjoyed them in my 20X15 with vaulted ceiling listening room. But I felt like something was missing. I had a great sub going with them but there was just some depth that was not there. After speaking with Axiom and discussing my situation, 60's were recommended. MMMM MMM MMMMMM, just what I was looking for. The first track on the first disc that I played I was like. .. . eureka! that is what I was looking for. I think with a room your size you might have somewhat of the same experience.

Oh and did I mention that the 60's are wonderful.