Gmorf, it's not just which feels better to you in your hand, but how accessible the buttons are when it is in your hand. The thing I love most about my URC MX-85O, is it's ergonomic layout.
In addition to laying comfortably in my hand, the most used buttons, the ones between the screen at the top of the remote, and the numbered buttons at the bottom (volume, channel, previous channel, mute, guide, info, joystick, etc.), are easily accessible by my thumb, meaning that most operations are one handed. It is possible to use the screen buttons and the numbered buttons with just one hand if your hand is big enough, but, to me, using a second hand is a bit more convenient.
I've no real experience with the Harmony, and would not be a bit surprised if they have equally well designed ergonomics. I mention the above merely to remind you to compare the ergonomics of both to see if you have a preference.
