[snip] I've no real experience with the Harmony, and would not be a bit surprised if they have equally well designed ergonomics. I mention the above merely to remind you to compare the ergonomics of both to see if you have a preference.
It's not even close. Harmony buttons along the LED screen are beyond horrible. It's tiny and it's very hard to operate by feel alone. It's not a bad remote; it's just that it's not even close to the URC line.