I think you really need to listen to some speakers and decide how they fit with your music taste. The 22's tell you like it is and if a classic rock recording of yours isnt that great, they will not be forgiving. I have some Neil Young that doesnt sound that good, but Stevie Ray Vaughn that is great on my 22's.
I personally like the M80's much more than the 60's. In fact I prefer the sound of M22's with a sub to the M60's...but that is just my preference.
You can easily get by with 22's, VP150 and QS4 or 8's for HT and music in DPL, but if you are very critial and like 2ch music, then you may want to step up to M80's. Find somebody in your area and get an audition if you can.