Since the 5 1/4" mid-range of the M22(and VP160)is the same as that in the M80s, that would be a preferable match. Note that the VP160 configuration can be viewed as a vertical center flanked by woofers to handle the bass.

If the center would have the tweeter at a position significantly different from ear level, it would be good to tilt it slightly so as to point at the ears.

-----------------------------------

Enjoy the music, not the equipment.