I currently have a similar system in my upstairs living room until I complete my new downstairs HT room. Except for the sub, which I have the EP350, it works fine. Of course I'm not cranking it up as much as I will downstairs.
Current room size is about 15' x 20' with 9' ceilings.


M60ti's, VP150, EP350, 4 Qs8's
Sanyo Z2 projector
Denon 2805
Samsung OTA HD receiver
Toshiba Prog. DVD player

M80s VP180 4xM22ow 4xM3ic EP600 2xEP350
AnthemAVM60 Outlaw7700 EmoA500 Epson5040UB FluanceRT85